SMID PIETER,IWEMA BAKKER WOUTER I.,COOLEN HEIN K. A. C.,SLIEDREGT LEONARDUS A. J. M.,VAN DONGEN MARIA J. P.,DEN HARTOG JACOBUS A. J.
申请号：
ARP110102455
公开号：
AR082136A1
申请日:
2011.07.08
申请国别(地区):
AR
年份:
2012
代理人:
摘要：
This compound has affinity with SGP receptor and can be used for treatment, Mitigation or prevention of disease and disease (any) the recipient involves or involves regulating the local SGP signal system through any recipient, SGP. Requirements 1: a mixed non periodic derivative of R1 selected from formula (1) Ciano； alquenilo c2-4, c2-4 tar, C1-4 tar, each can be replaced by CN or one or more fluorine atoms； cyclo C3-6, cyclo-6, C4-6 or double cycle C8-10 group,Each substitute is replaced by halogen or C1-4 tar, and the substitute is one or more fluorine atoms； for phenyl, biphenyl, northwest Africa, each substitute is replaced by one or more selected substitutes, which are free of halogen, cyanogen, C1-4 tar, and the substitute is one or more fluorogens, alcox C1-4. One or more fluorine, amino, diethylamine and cyclopropyl compound C3-6 atoms are selected to replace it with phenyl, which can be replaced by C1-4 tar or halogen； phenyl, benzene, phenyl or monocyclic heterocyclic compound is used to replace phenyl, each of which can be selectively replaced by C1-4 tar；Z is a contact group - W - (tar CN) - t - where W is added to R1 and O - is selected from the link,- I...- yes.-So...-SO2...- en...-CH=CH---C (CF3) 3DCH--C...-Yeah. - yeah-O-CO-O-O- uh huh...-NH-CO- and trans-cyclopropylene； n is an integer from 0 to 10； and T adheres to the phenylene / pyridyl functional group and is selected from a bond, -O-,- yes.-So...-SO2...- en...- I...-C=C-C...In addition, one or more halogen atoms or optional C1-4 tar replaced by one or more halogen atoms or optional C1-4 ring structure replaced by one or more halogen atoms are also selected； the structure of ring a can contain one nitrogen atom； X from C or N； if x is C, R3 is selected from H and C1-4 tar, otherwise R3 is not present； and it is selected from NH, O and S； Q structure is a 5, 6 or 7-member annular ammonia water；R4 is a c1-4-r5 tar, in which one or more carbon atoms in the tar group can be independently replaced b
