The present disclosure relates to compounds useful as modulators of nAChR A7, including the components of these compounds, and the use of these compounds to prevent, treat or improve diseases, in particular central nervous system disorders, such as cognitive disorders in Alzheimer's disease, Parkinson's disease and schizophrenia, as well as schizophrenia and inflammation caused by L-DOPA. Claim 1: a formulated compound (1),Or select the acceptable salt of X from the formula group (2)；And 1 to 4 substituents are selected, each independently selected from H, C₁₋₄ alkyl,Halogens and oh, if the tar is replaced by one or more halogens or Oh； a is an isomerization ring composed of 5 members, replaced by 1-3 R groups, each R group is independent of ox8311； r83212；CN alcoxi hal geno aminoalquilo hidroxialquilo alquilo cicloalquilo arilo heteroarilo y heterociclilo estando dichos alcoxi aminoalquilo hidroxialquilo alquilo cicloalquilo arilo heteroarilo y heterociclilo opcionalmente sustituidos con uno o m s sustituyentes seleccionados independientemente de F Cl Br OH oxo CFOCF83223,CN, C₁₋₆ alkyl,O-C₁₋₄ alkyl,S-lease c831832421；C = 0 - lessor c8321c83318324；(C 3DO) NR R(C 3DO) ORC₁₋₄ alkynyl,C₃₋₆ cycloalkyl,C₃₋₆ O-cycloalkyl,C = O-C₃₋₆ cycloalkyl,1. Arilo, amphibole and isopropyl, whether asphalt, isopropyl or non propyl isopropyl, are independently replaced by one or more halogens, cf832323；Oh and oxo； R1 is h or C 832183；R² is H or C₁₋₄ alkyl；R3: H, halogen or c832183 / 833318324；1. This alternative tar is one or more halogens； r83088 is h, halogens or c832183314；said alkyl being optionally substituted with one or more halogen； or, R³ and R⁴ may optionally be linked together to form a cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl ring, said ring being optionally substituted with one or more substituents independently selected from OH, halogen or C₁₋₄ alkyl；H h or c8332131；832431, block r8310h or c8332131；832431, rental block r831111h or c8332131；R⁸ is H or C₁₋₄ alkyl
