MCCALL, JOHN M.,MCKEARN, JOHN,ROMERO, DONNAL L.,CLARE, MICHAEL
申请号：
ES10814524
公开号：
ES2534226T3
申请日:
2010.09.02
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of structural formula IV: ** Formula ** or one of its salts or esters, wherein: Rz is selected from OH, NR8, R9, NR8OR9； R1 is selected from aryl and heteroaryl, any of which may be optionally substituted with one or more substituents selected from hydrogen, halo, alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl, aryl, aralkyl, heterocyclyl, heteroaryl, heteroarylalkyl, CN , alkoxy, alkylamino, dialkylamino, NHSO2R12, NHSO2NHR12, NHCOR12, NHCONHR12, CONHR12, CONR12aR12b, hydroxy, SO2R12, SO2NHR12, CF3 and OCF3； R3 is selected from hydrogen, hydroxyl, C1-C5 alkyl and C1-C5 alkoxy, any of which may be optionally substituted； R5 and R6 are independently selected from hydrogen, C1-C6 alkyl, C1-C7 cycloalkyl, C1-C7 heterocycloalkyl, C1-C6 alkenyl, C1-C6 alkynyl, aryl, heteroaryl, aralkyl and heteroaralkyl, or taken together, R5 and R6 may form a heterocycloalkyl or heteroaryl, any of which may be optionally substituted； R8 and R9 are each independently selected from hydrogen, C1-C6 alkyl, aryl, heteroaryl, aralkyl and heteroaralkyl, any of which may be optionally substituted； and R12, R12a and R12 b are independently selected from hydrogen, C1-C6 alkyl, aryl, heteroaryl, aralkyl, CF3 and heteroaralkyl, any of which may be optionally substituted.Un compuesto de fórmula estructural IV:**Fórmula** o una de sus sales o ésteres, en donde: Rz se selecciona de entre OH, NR8, R9, NR8OR9； R1 se selecciona de entre arilo y heteroarilo, cualquiera de los cuales puede estar opcionalmente sustituido con uno o más sustituyentes seleccionados de entre hidrógeno, halo, alquilo, alquenilo, alquinilo, cicloalquilo, haloalquilo, arilo, aralquilo, heterociclilo, heteroarilo, heterarilalquilo, CN, alcoxi, alquilamino, dialquilamino, NHSO2R12, NHSO2NHR12, NHCOR12, NHCONHR12, CONHR12, CONR12aR12b, hidroxi, SO2R12, SO2NHR12, CF3 y OCF3； R3 se selecciona de entre hidrógeno, hidroxilo, alquilo C1-C5 y alcoxi C1-C5, cualquiera de los cuales puede estar opcionalmente sustituido； R5 y R6 se
