서울대학교산학협력단;SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION;SNU R&DB FOUNDATION
发明人:
YUN, CHEOL HEUI,윤철희,PARK, SUNG MOO,박성무,GU, MIN JEONG,구민정,HAN, SEUNG HYUN,한승현,YUN, CHEOL HEUIKR,PARK, SUNG MOOKR,GU, MIN JEONGKR,HAN, SEUNG HYUNKR
申请号：
KR1020140081005
公开号：
KR1020160007792A
申请日:
2014.06.30
申请国别(地区):
KR
年份:
2016
代理人:
摘要：
The present invention relates to a method of protecting a livestock intestinal barrier using Bacillus subtilis and, more particularly, to a composition for protecting the livestock intestinal barrier from damages of a livestock intestinal barrier due to deoxynivalenol, the composition containing heat-treated Bacillus subtilis as an active ingredient, and a method of protecting the livestock intestinal barrier from damages of the livestock intestinal barrier due to deoxynivalenol, the method including the step of performing oral administration of the composition on livestock. A composition for protecting the livestock intestinal barrier from damages of a livestock intestinal barrier due to deoxynivalenol contains heat-treated Bacillus subtilis as an active ingredient. The heat-treatment process is performed on a Bacillus subtilis culture medium at 100 °；C to 130 °；C for 15 minutes to 90 minutes. The Bacillus subtilis reduces the permeability of epithelial cells for a pig intestinal barrier. The Bacillus subtilis increases expression of tight junction proteins in the epithelial cells for the pig intestinal barrier. The livestock is a pig. A composition including heat-treated Bacillus subtilis as an active ingredient may prevent deterioration of pig rearing, and may furthermore prevent economic losses of pig farms by protecting intestinal barriers of pigs from fungal infections.본 발명은 열 처리된 바실러스 서브틸리스를 유효성분으로 함유하는, 데옥시니발레놀(deoxynivalenol)에 의한 장관벽 손상으로부터 가축 장관벽을 보호하기 위한 조성물 및 상기 조성물을 가축에게 경구 투여하여 데옥시니발레놀에 의한 장관벽 손상으로부터 가축 장관벽을 보호하는 방법에 관한 것으로, 돈육 농가의 경제적 손실을 예방할 수 있다.
