PROBLEM TO BE SOLVED: To provide methods and compositions which comprise effective amounts of analgesics to treat a subject, including reducing or eliminating an adverse effect associated with the analgesics.SOLUTION: A bilayer tablet composition has an immediate-release layer and a controlled-release layer containing (1) effective amounts of (a) an opioid analgesic such as hydrocodone, oxycodone and morphine, (b) a stimulant such as aminophylline, caffeine and dyphylline, and (c) an antiemetic such as aprepitant, dronabinol and perphenazine, and (2) a pharmaceutically acceptable carrier or vehicle.SELECTED DRAWING: None【課題】鎮痛薬に関連する有害作用の軽減または消失を含む、被験体の治療に有効な量の鎮痛薬を含む方法および組成物の提供。【解決手段】（１）有効量の（ａ）ヒドロコドン、オキシコドン、モルヒネ等のオピオイド鎮痛薬、（ｂ）アミノフィリン、カフェイン、ジフィリン等の刺激薬、（ｃ）アプレピタント、ドロナビノール、ペルフェナジン等の制吐薬、および（２）薬学的に許容可能なキャリアまたはビヒクルを含む制御放出層および即放層を有する二層錠剤組成物。【選択図】なし
