PROBLEM TO BE SOLVED: To provide a composition comprising an analgesic at an effective amount of treatment for a subject including alleviation or elimination of an adverse effect related to the analgesic, and a formulation method thereof.SOLUTION: A composition comprises (1) an effective dose of (a) an opioid analgesic, (b) a stimulant, (c) an antiemetic, and (2) a pharmaceutically acceptable carrier or vehicle, and specifically the composition comprises (1) an effective dose of (a) oxycodone morphine, butalbital, or a pharmaceutically acceptable salt thereof, (b) promethazine or a pharmaceutically acceptable salt thereof, (c) modafinil or a pharmaceutically acceptable salt thereof and (d) naltrexone or a pharmaceutically acceptable salt thereof, and (2) a pharmaceutically acceptable carrier or vehicle.【課題】鎮痛薬に関連する有害作用の軽減または消失を含む、被験体の治療に有効な量の鎮痛薬を含む組成物及びその処法の提供。【解決手段】（１）有効量の（ａ）オピオイド鎮痛薬、（ｂ）刺激薬、（ｃ）制吐薬、及び（２）薬学的に許容可能なキャリア又はビヒクルを含む組成物で、詳しくは（１）有効量の（ａ）オキシコドンモルヒネ、ブタルビタール等又はそれらの薬学的に許容可能な塩、（ｂ）プロメタジン又はその薬学的に許容可能な塩、（ｃ）モダフィニル又はその薬学的に許容可能な塩、および（ｄ）ナルトレキソン又はその薬学的に許容可能な塩、並びに（２）薬学的に許容可能なキャリアまたはビヒクルを含む組成物。【選択図】なし
