#$%^&*AU2014250614A120141113.pdf#####The present invention relates to abuse-resistant, sustained-release dosage forms comprising opioids , and provides for sequestering subunits comprising an antagonist and an agonist. The subunit comprise of an antagonist in a first layer and an agonist in a second layer, upon said first layer such that the antagonist is substantially sequestered when administered to a human being in an intact form, such that physical disruption of the dosage form decreases the euphoric effect of the agonist when administered to a person as compared to an immediate release agonist composition. In a preferred embodiment, the agonist is morphine, and the antagonist is naltrexone. Pharmaceutical compositions comprising said subunit are also provided.WO 2009/032270 PCT/US2008/010357 1/27 20 18 16 14 12 10 6 ----- --------2 0 0 0.5 1 1.5 2 3 4 6 8 MORPHINE -- WHOLE CRUSHED --------- PLACEBO FIG. 1
