HUNTER, ALAN,LINKE, THOMAS,PABST, TIM,WENDELER, MICHAELA,WANG, XIANGYANG,TOHMPSON, CHRIS,XI, GUOLING,FULTON, ANDREW
申请号:
EP13863999
公开号:
EP2934597A4
申请日:
2013.12.19
申请国别(地区):
EP
年份:
2016
代理人:
摘要:
The present invention provides methods of preparing active immunoconjugates, including anti-CD22 immunoconjugates. Suitably, the methods include a fed-batch refolding process and/or column stripping process that result in an increase in yield of the immunoconjugate over other processes that do not utilize the methods.