Hunter, Alan,Linke, Thomas,Pabst, Tim,Wendeler, Michaela,Wang, Xiangyang,Thompson, Chris,Xi, Guoling,Fulton, Andrew
申请号:
AU2013361235
公开号:
AU2013361235B2
申请日:
2013.12.19
申请国别(地区):
AU
年份:
2018
代理人:
摘要:
The present invention provides methods of preparing active immunoconjugates, including anti-CD22 immunoconjugates. Suitably, the methods include a fed-batch refolding process and/or column stripping process that result in an increase in yield of the immunoconjugate over other processes that do not utilize the methods.