Alan Hunter,Thomas Linke,Timothy Pabst,Michaela Wendeler,Xiangyang Wang,Christopher Thompson,Guoling Xi,Andrew Fulton
申请号：
US14654384
公开号：
US09920124B2
申请日:
2013.12.19
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention provides methods of preparing active immunoconjugates, including anti-CD22 immunoconjugates. Suitably, the methods include a fed-batch refolding process and/or column stripping process that result in an increase in yield of the immunoconjugate over other processes that do not utilize the methods.
