MACDONALD LYNN,MURPHY ANDREW J.,MCWHIRTER JOHN,GURER CAGAN,MEAGHER KAROLINA,TU NAXIN,VORONINA VERA,STEVENS SEAN
申请号：
NZ62314712
公开号：
NZ623147A
申请日:
2012.10.26
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
Disclosed is a genetically modified non-human animal, comprising in its genome: -an unrearranged T cell receptor (TCR) &alpha variable gene locus comprising at least one human V&alpha segment and at least one human J&alpha segment, wherein the TCR&alpha variable gene locus is operably linked to a non-human TCR&alpha constant gene sequence, wherein the unrearranged TCR&alpha variable gene locus replaces an endogenous non-human TCR&alpha variable gene locus, and/or -an unrearranged TCR&bgr variable gene locus comprising at least one human V&bgr segment, at least one human D&bgr segment, and at least one human J&bgr segment, wherein the unrearranged TCR&bgr variable gene locus is operably linked to a non-human TCR&bgr constant gene sequence, wherein the unrearranged TCR&bgr variable gene locus replaces an endogenous non-human TCR&bgr variable gene locus.
