Byung-Heon Lee;Jae-Sung Bae;Hee Kyoung Jin;Hyung Soo Han;In San Kim
发明人:
Byung-Heon Lee,In San Kim,Jae-Sung Bae,Hee Kyoung Jin,Hyung Soo Han
申请号：
US13469729
公开号：
US20120288447A1
申请日:
2012.05.11
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention relates to a peptide that passes through a blood-brain barrier and targets apoptosis of neurodegenerative brain disease-affected sites and uses thereof. More particularly, the present invention relates to a composition for delivering drugs to brain tissues, a composition for detecting apoptotic cells of neurodegenerative brain disease-affected sites, and a composition for imaging the neurodegenerative brain disease-affected sites which comprises a peptide having an amino acid sequence represented by SEQ ID: No. 1 respectively, and a composition for prevention, treatment, or theranosis of neurodegenerative brain diseases comprising said peptide. The peptide of the present invention can be used for detecting apoptosis in neurodegenerative brain diseases and further detecting apoptotic cells (especially apoptotic neuronal cells) in neurodegenerative brain disease-affected sites and imaging, targeted drug delivery, theranosis.
