BABICH, JOHN W.,巴比希 约翰Ｗ.,巴比希 約翰Ｗ.,ZIMMERMAN, CRAIG N.,齐麦曼 克雷格Ｎ.,齊麥曼 克雷格Ｎ.,MARESCA, KEVIN P.,马瑞斯卡 凯文Ｐ.,馬瑞斯卡 凱文Ｐ.,巴比希 约翰W.,巴比希 約翰W.,齐麦曼 克雷格N.,齊麥曼 克雷格N.,马瑞斯卡 凯文P.,馬瑞斯卡 凱文P.
申请号：
TW096142019
公开号：
TWI492761B
申请日:
2007.11.07
申请国别(地区):
TW
年份:
2015
代理人:
摘要：
Compounds of Formula (Ia)wherein R is a C6-C12substituted or unsubstituted aryl, a C6-C2substituted or unsubstituted heteroaryl, a C1-C6substituted or unsubstituted alkyl or-NR'R', Q is C(O), O, NR', S, S(O)2, C(O)2(CH2)p Y is C(O), O, NR', S, S(O)2, C(O)2(CH2)p Z is H or C1-C4alkyl, R' is H, C(O), S(O)2, C(O)2, a C6-C12substituted or unsubstituted aryl, a C6-C12substituted or unsubstituted heteroaryl or a C1-C6substituted or unsubstituted alkyl, when substituted, aryl, heteroaryl and alkyl are substituted with halogen, C6-C12heteroaryl, -NR'R' or COOZ, which have diagnostic and therapeutic properties, such as the treatment and management of prostate cancer and other diseases related to NAALADase inhibition. Radiolabels can be incorporated into the structure through a variety of prosthetic groups attached at the X amino acid side chain via a carbon or hetero atom linkage.本發明係有關於具有診斷及治療性質，諸如攝護腺癌及與NAALAD酶抑制作用有關之其它疾病的治療及處理之式(Ia)化合物其中R為C6-C12取代或未經取代之芳基、C6-C12取代或未經取代之雜芳基、C1-C6取代或未經取代之烷基或-NR'R'，Q為C(O)、O、NR'、S、S(O)2、C(O)2、(CH2)pY為C(O)、O、NR'、S、S(O)2、C(O)2、(CH2)pZ為H或C1-C4烷基，R'為H、C(O)、S(O)2、C(O)2、C6-C12取代或未經取代之芳基、C6-C12取代或未經取代之雜芳基或C1-C6取代或未經取代之烷基，當經取代時，芳基、雜芳基及烷基係經鹵素、C6-C12雜芳基、-NR'R'或COOZ取代。
