A compound which inhibits both of EGF receptor tyrosine kinase and HER2 tyrosine kinase is provided. A compound represented by the general formula (I): wherein R X is a group represented by the formula: wherein R 1 is a hydrogen atom, optionally substituted alkyl, etc.； Z is -O-, -N(R 10 )-, etc.； R 10 is a hydrogen atom, alkyl, etc.； R 2 is a hydrogen atom, optionally substituted alkyl, etc.； R 18 is a hydrogen atom, optionally substituted alkyl, etc.； R 19 is optionally substituted alkyl, etc.； W 1 is an optionally substituted non-aromatic nitrogen-containing group； R 17 is a hydrogen atom, optionally substituted alkyl, etc.； R 3 and R 4 are independently a hydrogen atom, optionally substituted alkyl, etc.； X is -O-, -S-, or -N(R 12 )-, etc.； R 12 is a hydrogen atom, alkyl, etc.； and A is phenyl optionally having a substituent, etc., its pharmaceutically acceptable salt, or a solvate thereof.本發明提供可抑制EGF受體酪胺酸激活酶及HER2酪胺酸激活酶二者之化合物。；係為式(I)：；(I)；〔式中，RX為如下式：； ， ， ，或；(式中，R1為氫、可被取代之烷基等；Z為-O-、-N(R10)-等；R10為氫、烷基等；R2為氫、可被取代之烷基等；R18為氫、可被取代之烷基等；R19為可被取代之烷基等；W1為可被取代之非芳香族含氮雜環基；R17為氫、可被取代之烷基等)之基；R3及R4各為氫、可被取代之烷基、等；X為-O-、-S-、或-N(R12)-等；R12為氫、烷基等；及A為可有取代基之苯基等)之基〕之化合物或其製藥容許鹽或其溶劑合物。
