Forman, Stephen J.,Brown, Christine E.,Jonnalagadda, Umamaheswararao,Mardiros, Armen
申请号：
EP14877876
公开号：
EP3094653A4
申请日:
2014.03.14
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
Adoptive immunotherapy using T cells genetically redirected via expression of chimeric antigen receptors (CARs) is a promising approach for cancer treatment. However, this immunotherapy is dependent in part on the optimal molecular design of the CAR, which involves an extracellular ligand-binding domain connected to an intracellular signaling domain by spacer and/or transmembrane sequences.
