Stephen J. Forman;Umamaheswararao Jonnalagadda;Armen Mardiros;Christine E. Brown
发明人:
Stephen J. Forman,Christine E. Brown,Umamaheswararao Jonnalagadda,Armen Mardiros
申请号：
US15111384
公开号：
US20160333108A1
申请日:
2014.03.14
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Adoptive immunotherapy using T cells genetically redirected via expression of chimeric antigen receptors (CARs) is a promising approach for cancer treatment. However, this immunotherapy is dependent in part on the optimal molecular design of the CAR, which involves an extracellular ligand-binding domain connected to an intracellular signaling domain by spacer and/or transmembrane sequences.
