PROBLEM TO BE SOLVED: To provide a uroplakin expression promoter for promoting the expression of uroplakin in bladder epithelial cells, and to take advantage of the efficacy of the uroplakin expression promoter and to administer uroplakin, urinary urgency, urinary incontinence or bladder pain as a means of its administration. A preventive or ameliorating agent and an agent for preventing or ameliorating vesicoureteral reflux are provided. An uroplakin expression promoter, an agent for preventing or improving urinary frequency, urinary urgency, urinary incontinence or bladder pain, comprising at least one active ingredient selected from the group consisting of glucosamine, pyruvic acid and salts thereof, and a bladder An agent for preventing or improving ureteral reflux disease. [Selection figure] None【課題】膀胱上皮細胞におけるウロプラキンの発現を促進するウロプラキン発現促進剤、並びに前記ウロプラキン発現促進剤の効能を生かし、またその投与の手段としての、頻尿、尿意切迫感、尿失禁又は膀胱痛の予防又は改善剤、及び膀胱尿管逆流症の予防又は改善剤を提供する。【解決手段】グルコサミン、ピルビン酸及びこれらの塩からなる群より少なくとも１種を有効成分とする、ウロプラキン発現促進剤、頻尿、尿意切迫感、尿失禁又は膀胱痛の予防又は改善剤、及び膀胱尿管逆流症の予防又は改善剤。【選択図】なし
