PROBLEM TO BE SOLVED: To provide an uroplakin expression promoter which promotes uroplakin expression in a bladder epithelial cell, and a preventive or an improver of frequent urination, urinary urgency, urinary incontinence or bladder pain which makes good use of efficacy of the uroplakin expression promoter or as its administering means, and a preventive or an improver of vesicoureteral reflux.SOLUTION: There are provided an uroplakin expression promoter having glucosamine, pyruvic acid and at least one type from the group consisting of salt thereof as an active ingredient, a preventive or an improver of frequent urination, urinary urgency, urinary incontinence or bladder pain, and a preventive or an improver of vesicoureteral reflux.SELECTED DRAWING: NoneCOPYRIGHT: (C)2016,JPO&INPIT【課題】膀胱上皮細胞におけるウロプラキンの発現を促進するウロプラキン発現促進剤、並びに前記ウロプラキン発現促進剤の効能を生かし、またその投与の手段としての、頻尿、尿意切迫感、尿失禁又は膀胱痛の予防又は改善剤、及び膀胱尿管逆流症の予防又は改善剤を提供する。【解決手段】グルコサミン、ピルビン酸及びこれらの塩からなる群より少なくとも1種を有効成分とする、ウロプラキン発現促進剤、頻尿、尿意切迫感、尿失禁又は膀胱痛の予防又は改善剤、及び膀胱尿管逆流症の予防又は改善剤。【選択図】なし
