PROBLEM TO BE SOLVED: To provide an Uroplakin expression promoting agent that accelerates expression of Uroplakin in bladder epithelial cells as well as an agent for prevention or improvement of vesicoureteral reflux as means for administration thereof.SOLUTION: The invention provides an Uroplakin expression promoting agent comprising Perilla frutescens extract as an active ingredient. The invention also provides an agent for preventing or improving vesicoureteral reflux.SELECTED DRAWING: Figure 2【課題】膀胱上皮細胞におけるウロプラキンの発現を促進するウロプラキン発現促進剤、並びに前記ウロプラキン発現促進剤の効能を生かし、またその投与の手段としての膀胱尿管逆流症の予防又は改善剤を提供する。【解決手段】シソ(Perillafrutescens)抽出物を有効成分とする、ウロプラキン発現促進剤、並びに膀胱尿管逆流症の予防若しくは改善剤。【選択図】図2
