The Regents of The University of Colorado; A Body Corporate
发明人:
CARUTHERS, Marvin,PAUL, Sibasish
申请号：
EP17853706
公开号：
EP3515445A4
申请日:
2017.09.15
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
Amine substituted morpholino oligonucleotides, other than the classical N,N-dimethylamino PMO analogue, and methods of efficiently synthesizing these oligonucleotides with high yield are provided. Morpholino oligonucleotides having thiophosphoramidate, phosphoramidate, and alkyl phosphoramidate linkers. Chimeras containing unmodified DNA/RNA and other analogs of DNA/RNA can be prepared. These oligonucleotides form duplexes with complementary DNA or RNA that are more stable than natural DNA or DNA/RNA complexes, are active with RNAse H1, and may be transfected into cells using standard lipid reagents. These analogues are therefore useful for numerous applications.
