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A COLLAGEN/HYDROXYAPATITE COMPOSITE SCAFFOLD
专利权人:
Royal College of Surgeons in Ireland
发明人:
OBRIEN FERGAL,GLEESON JOHN,PLUNKETT NIAMH
申请号:
PL12178368
公开号:
PL2517738T3
申请日:
2008.02.11
申请国别(地区):
PL
年份:
2018
代理人:
摘要:
A process for producing a collagen/hydroxyapatite (HA) composite scaffold comprises the steps of forming a homogenous suspension of collagen and HA in an acidic solution, lyophilising the suspension until a desired final freezing temperature is reached to produce the composite scaffold, and optionally cross-linking the composite scaffold, wherein the ratio of HA to collagen is at least 1:10 (w/w).Also provided is a collagen/hydroxyapatite (HA) composite scaffold comprising a homogenous distribution of hydroxyapatite within a porous, crosslinked, collagen matrix, wherein the ratio of HA to collagen is at least 1:10 (w/w). Suitably, the composite scaffold has a porosity of at least 99% (v/v), and a compressive stiffness of at least 0.3KPa. Composite scaffolds of the invention may be used to provide osteoconductive bone implants and tissue engineering implants.
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