Федеральное государственное бюджетное учреждение "Федеральный научный центр трансплантации и искусственных органов имени академика В.И. Шумакова" Министерства здравоохранения Российской Федерации (RU)
发明人:
Севастьянов Виктор Иванович (RU),Попов Владимир Карпович (RU)
申请号：
RU2013117951/15
公开号：
RU2013117951A
申请日:
2013.04.19
申请国别(地区):
RU
年份:
2014
代理人:
摘要：
1. The bioactive resorbable porous 3D-matrix for tissue engineering, which is a composite material of synthetic resorbable part-crystalline polymer for medical purposes as a 3D-matrix with a pore size in the range from 2 to 100 microns, a porosity of 60-80% and incorporated into part its pore heterogeneous biopolymer gel with particle size 30-100 microns module viscosity 15-70 Pa and a modulus 45-1200 Pa in a ratio of polymer / gel is from 99: 1 to 50:50 wt%, with the value of the contact angle of wetting of the matrix surface. water from 60 ° to 20 ° sootvetstvenno.2. The bioactive resorbable porous 3D-matrix for tissue engineering according to claim 1, wherein the biopolymer comprises a heterogeneous gel fuktsionalnye additive selected from the group of: hydroxyapatite, growth factors, cytokines, anti-oxidants or smesi.3. A method of producing a bioactive resorbable porous 3D-matrix for tissue engineering, in which the powder mixture was mechanically triturated resorbable synthetic partially crystalline polymer medical devices and heterogeneous biopolymer gel in a ratio of polymer / gel is from 99:. 1 to 50:50% by weight, the prepared mixture is filled mold previously defatted and peeled COpri supercritical temperature of 60 ° C, a pressure of 20 MPa for 1 hour, then filled mold was placed in a pressure chamber where the dressing shayut first temperature to 25-40 ° C, and then - COdo pressure 4,0-25,0 MPa and maintained the system under these conditions for 1 hour and then for 30-120 min depressurized in the pressure chamber to atmospheric value, and then cooled to room temperature and remove about1. Биоактивный резорбируемый пористый 3D-матрикс для тканевой инженерии, представляющий собой композиционный материал из резорбируемого синтетического частично-кристаллического полимера медицинского назначения в виде 3D-матрикса с размером пор в диапазоне от 2 до 100 мкм, пористостью 60-80% и инкорпорированного в часть его пор биополимерного гетерогенного геля с размером
