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שלד מרוכב של קולגן/הידרוקסיאפטיט ותהליך להכנתו
专利权人:
ROYAL COLLEGE OF SURGEONS IN IRELAND
发明人:
申请号:
IL20029509
公开号:
IL200295A
申请日:
2009.08.09
申请国别(地区):
IL
年份:
2015
代理人:
摘要:
A process for producing a collagen/hydroxyapatite (HA) composite scaffold comprises the steps of forming a homogenous suspension of collagen and HA in an acidic solution, lyophilising the suspension until a desired final freezing temperature is reached to produce the composite scaffold, and optionally cross-linking the composite scaffold, wherein the ratio of HA to collagen is at least 1:10 (w/w).Also provided is a collagen/hydroxyapatite (HA) composite scaffold comprising a homogenous distribution of hydroxyapatite within a porous, crosslinked, collagen matrix, wherein the ratio of HA to collagen is at least 1:10 (w/w). Suitably, the composite scaffold has a porosity of at least 99% (v/v), and a compressive stiffness of at least 0.3KPa. Composite scaffolds of the invention may be used to provide osteoconductive bone implants and tissue engineering implants.
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