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Collagen / hydroxyapatite composite skeleton and method for producing the same
专利权人:
ロイヤル カレッジ オブ サージョンズ イン アイルランド
发明人:
オブライエン, ファーガル,グレッソン, ジョン,プランケット, ニーアム,オブライエン, ファーガル,グレッソン, ジョン,プランケット, ニーアム
申请号:
JP2009548796
公开号:
JP5527760B2
申请日:
2008.02.11
申请国别(地区):
JP
年份:
2014
代理人:
摘要:
A process for producing a collagen/hydroxyapatite (HA) composite scaffold comprises the steps of forming a homogenous suspension of collagen and HA in an acidic solution, lyophilising the suspension until a desired final freezing temperature is reached to produce the composite scaffold, and optionally cross-linking the composite scaffold, wherein the ratio of HA to collagen is at least 1:10 (w/w).Also provided is a collagen/hydroxyapatite (HA) composite scaffold comprising a homogenous distribution of hydroxyapatite within a porous, crosslinked, collagen matrix, wherein the ratio of HA to collagen is at least 1:10 (w/w). Suitably, the composite scaffold has a porosity of at least 99% (v/v), and a compressive stiffness of at least 0.3KPa. Composite scaffolds of the invention may be used to provide osteoconductive bone implants and tissue engineering implants.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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