HITE, MICHAEL,FEDERICI, CATHY,BRUNELLE, ALAN,TURNER, STEPHEN
申请号：
CA2582150
公开号：
CA2582150C
申请日:
2005.09.30
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The present invention is a solid dosage form for oral administration ofibuprofen comprising a modified release formulation of ibuprofen whichprovides an immediate burst effect and thereafter a sustained release ofsufficient ibuprofen to maintain blood levels at least 6.4 ~g/ml over anextended period of at least 8 hours following administration of a single dose.The dosage form releases ibuprofen at a rate sufficient to initially deliver aeffective amount of ibuprofen within about 2.0 hours following administration.The dosage form then subsequently delivers the remaining amount of ibuprofenat a relatively constant rate sufficient to maintain a level of ibuprofen overa predetermined delivery period of for at least 8 hours.
