The present invention provides a gastro-retentive pharmaceutical dosage form comprising a therapeutically effective amount of at least one GABA Analog, at least one opioid, and at least one pharmaceutically acceptable excipient wherein the said dosage form is retained in the stomach for at least four hours and is suitable for once daily or twice daily administration. The present invention further provides a method of treating a disorder by administering to a patient in need thereof, a gastro-retentive pharmaceutical dosage form comprising a therapeutically effective amount of at least one GABA Analog, at least one opioid, and at least one pharmaceutically acceptable excipient wherein the said dosage form is retained in the stomach for at least four hours and is suitable for once daily or twice daily administration. The said opioid is either in slow release form or in immediate release form.
