The present invention provides a gastro-retentive pharmaceutical dosage form comprising a therapeutically effective amount of at least one opioid, at least one form of acetaminophen, and at least one pharmaceutically acceptable excipient wherein the said dosage form is retained in the stomach for at least four hours and is suitable for once daily or twice daily administration. The present invention further provides a method of treating pain by administering to a patient in need thereof, a gastro-retentive pharmaceutical dosage form comprising a therapeutically effective amount of at least one opioid, at least one form of acetaminophen, and at least one pharmaceutically acceptable excipient wherein the said dosage form is retained in the stomach for at least four hours and is suitable for once daily or twice daily administration. The acetaminophen is either in slow release form or in immediate release form or as combination of both. The present invention further provides a gastro-retentive pharmaceutical dosage form comprising a therapeutically effective amount of at least one opioid, at least one form of acetaminophen, an opioid antagonist and at least one pharmaceutically acceptable excipient, wherein the said dosage form is retained in the stomach for at least four hours and is suitable for once daily or twice daily administration.La présente invention concerne une forme médicamenteuse pharmaceutique à rétention gastrique comprenant une quantité thérapeutiquement efficace d'au moins un opioïde, au moins une forme d'acétaminophène, et au moins un excipient pharmaceutiquement acceptable. Ladite forme médicamenteuse est retenue dans l'estomac pendant au moins quatre heures et est appropriée pour une administration quotidienne ou biquotidienne. La présente invention porte en outre sur un procédé de traitement de la douleur par l'administration, à un patient en ayant besoin, d'une forme médicamenteuse pharmaceutique à rétention gastrique comprenant une quantité thérape
