JUNG, Sung Youb,JANG, Myung Hyun,SHEN, Ling Ai,PARK, Young Kyung,PARK, Young Jin,KWON, Se Chang
申请号：
PE0006332018
公开号：
PE12992018A1
申请日:
2012.06.07
申请国别(地区):
PE
年份:
2018
代理人:
摘要：
Referred to a Peptide comprising the following Amino Acid Sequence: R1 - X1 x2 X3 gtftsd - - - - - - - X4 X5 X6 X7 x8 X9 X10, x11 - - - - - - - X14 X12, X13 x15 - x16 x18 x19 - Concept - - - - - X20 X21 x22 X23 x24 - R2 where R1 is histidine.Desaminohistidilo, dimetilhistidilo (N - dimetilhistidilo), among others x1 is acid (AIB aminoisobutirico), D - alanine, Glycine, SAR (n-metilglicine)Serine or d-serine x2 is glutamic acid or glutamine or Leucine X3 is tyrosine, Serine or alanine is X4, X5 is lysine or arginine, glutamine and tyrosine is X6, X7 x8 is Leucine or methionine is acidic ASPArctic or X9 is glutamic acid, Serine, glutamic acid, alpha - metilglutamico or suppressed X10 is Glutamine, glutamic acid, Lysine, arginine, Serine or alanine X11 is, is deletedArginine, Valine or suppressed X12 is alanine, arginine, Serine, Valine or suppressed X13 is Lysine, arginine, glutamine, metilglutamico acid alpha - or suppressed x14 is Aspartic acid,Glutamic acid, Leucine or phenylalanine is suppressed x15 or suppressed x16 is isoleucine, Valine or suppressed x17 is alanine, cysteine, glutamic acid, glutamine, Lysine,Acid Alpha metilglutamico or suppressed x18 is tryptophan or suppressed x19 is alanine, isoleucine, Leucine, Serine, Valine or suppressed X20 is alanine, Lysine, methionine, glutamine,Arginine or suppressed X21 x22 is asparagine or suppressed is alanine, Glycine, threonine or x-23 is cysteine, is deletedLysine or suppressed x24 is a Peptide that has 2 to 10 amino acid combinations consisting of D alanine, Glycine and Serine, or suppressed and R2 is krnrnnia (SEQ ID no: 32)Gpssgappps (SEQ ID no 33), among others.This Peptide is derived from oxintomodulina capable of Activating the Receptor of glucagon like peptide-1 (CLP) - 1 and Glucagon Receptor better than the oxintomodulina NativeIt reduces food intake, gastric emptying and facilitates suppresses lipolysis with reduced side effectsAnd also shows excellent effects of Receptor Activators therefore, it can b
