PROBLEM TO BE SOLVED: To provide a prophylaxis or therapeutic agent of diarrhea having high safety to a living body.SOLUTION: Compounds having a calcium receptor activating action such as γ-Glu-X-Gly (X represents an amino acid or an amino acid derivative), γ-Glu-Val-Y (Y represents an amino acid or an amino acid derivative), γ-Glu-Ala, γ-Glu-Gly, γ-Glu-Cys, γ-Glu-Met, γ-Glu-Thr, γ-Glu-Val, γ-Glu-Orn, Asp-Gly, Cys-Gly, Cys-Met, Glu-Cys, Gly-Cys, Leu-Asp, γ-Glu-Met(O), γ-Glu-γ-Glu-Val, γ-Glu-Val-NH2, γ-Glu-Val-ol, γ-Glu-Ser, γ-Glu-Tau, γ-Glu-Cys(S-Me)(O), γ-Glu-Leu, γ-Glu-Ile, γ-Glu-t-Leu and γ-Glu-Cys(S-Me) are provided. A use of the compounds is also provided.COPYRIGHT: (C)2014,JPO&INPIT【課題】生体への安全性が高い下痢の予防又は治療剤の提供。【解決手段】カルシウム受容体活性化作用を有する化合物、例えばγ-Glu-X-Gly(Xはアミノ酸又はアミノ酸誘導体を表す)、γ-Glu-Val-Y(Yはアミノ酸又はアミノ酸誘導体を表す)、γ-Glu-Ala、γ-Glu-Gly、γ-Glu-Cys、γ-Glu-Met、γ-Glu-Thr、γ-Glu-Val、γ-Glu-Orn、Asp-Gly、Cys-Gly、Cys-Met、Glu-Cys、Gly-Cys、Leu-Asp、γ-Glu-Met(O)、γ-Glu-γ-Glu-Val、γ-Glu-Val-NH2、γ-Glu-Val-ol、γ-Glu-Ser、γ-Glu-Tau、γ-Glu-Cys(S-Me)(O)、γ-Glu-Leu、γ-Glu-Ile、γ-Glu-t-Leuおよびγ-Glu-Cys(S-Me)等とその利用。【選択図】図7
