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VLA-4 inhibitory drug
专利权人:
Nobuo Machinaga
发明人:
Nobuo Machinaga,Shin Iimura,Yoshiyuki Yoneda,Jun Chiba,Fumihito Muro,Hideko Hoh,Atsushi Nakayama
申请号:
US12097269
公开号:
US08129366B2
申请日:
2006.12.13
申请国别(地区):
US
年份:
2012
代理人:
摘要:
There is provided a VLA-4 inhibitory drug having good oral absorbability and exhibiting sufficient anti-inflammatory effects when administered orally.A compound represented by the following formula (I):wherein R1 represents a hydrogen atom or a C1-8 alkyl group R2 represents a hydrogen atom, a halogen atom, a C1-8 alkoxy group, or a benzyloxy group which may be substituted Q represents a monocyclic or bicyclic nitrogen-containing heterocyclic group which may be substituted, and has a nitrogen atom as the bonding site Y represents an oxygen atom or CH2 W represents a bicyclic aromatic hydrocarbon ring group which may be substituted, or a bicyclic aromatic heterocyclic group which may be substituted R3a, R3b and R3c each independently represent a hydrogen atom, a halogen atom, a C1-8 alkoxy group or a C1-8 alkyl group and A1 represents a nitrogen atom or C—R3d (wherein R3d represents a hydrogen atom, a halogen atom, a C1-8 alkoxy group or a C1-8 alkyl group),or a salt thereof, or a VLA-4 inhibitory drug comprising the compound or the salt as an active ingredient.
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