FREEHAUF, Keith,WALDRON, Niki,LÜTZ, Jürgen,GUERINO, Frank
申请号：
ES13717212
公开号：
ES2633611T3
申请日:
2013.04.03
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A soft chewable veterinary pharmaceutical composition for oral administration comprising an isoxazoline compound of Formula (I) ** Formula ** wherein R1>； = halogen, CF3, OCF3, CN, n>； = integer from 0 to 3, preferably 1, 2 or 3, R2>； = C1-C3 haloalkyl, preferably CF3 or CF2Cl, T>； = 5 or 6-membered ring, which is optionally substituted with one or more radicals Y, Y>； = methyl, halomethyl, halogen, CN , NO2, NH2-C>； = S, or two adjacent Y radicals together form a chain, especially a three or four member chain； Q>； = X-NR3R4 or a 5-membered N-heteroaryl ring, which is optionally substituted with one or more radicals； X>； = CH2, CH (CH3), CH (CN), CO, CS, R3>； = hydrogen, methyl, haloethyl, halopropyl, halobutyl, methoxymethyl, methoxyethyl, halomethoxymethyl, ethoxymethyl, haloethoxymethyl, propoxymethyl, ethylaminocarbonylmethyl, ethylaminocarbonylethyl, dimethylaminocarbonylethyl propynylaminocarbonylmethyl, N-phenyl-N-methylamino, haloethylaminocarbonylmethyl, haloethylaminocarbonylethyl, tetrahydrofuryl, methylaminocarbonylmethyl, (N, N-dimethylamino) -carbonylmethyl, propylaminocarbonylmethyl, cyclopropylaminocarbonylmethyl, propethylaminocyclopropylaminocyclopropylaminocyclopropylaminocyclopropylaminocyclopropylaminocyclopropylaminocarboxylaminocarboxylaminocarbonylcarbonylcarbonylcarbonylpropylaminocarbonylpropylaminocarbonylcarbonylcarbonylpropylaminocarbonylcarboxylaminocarboxylaminocarboxylaminocarboxylaminocarbonylUna composición farmacéutica veterinaria masticable blanda para administración oral que comprende un compuesto de isoxazolina de Fórmula (I)**Fórmula** en la que R1 >；= halógeno, CF3, OCF3, CN, n >；= número entero de 0 a 3, preferentemente 1, 2 o 3, R2 >；= haloalquilo C1-C3, preferentemente CF3 o CF2Cl, T >；= anillo de 5 o 6 miembros, que está opcionalmente sustituido con uno o más radicales Y, Y >；= metilo, halometilo, halógeno, CN, NO2, NH2-C>；=S, o dos radicales Y adyacentes forman juntos una cadena, especialment
