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VLA-4 inhibitory drug
专利权人:
Nobuo Machinaga;Shin Iimura;Yoshiyuki Yoneda;Atsushi Nakayama;Jun Chiba;Hideko Hoh;Fumihito Muro
发明人:
Nobuo Machinaga,Shin Iimura,Yoshiyuki Yoneda,Jun Chiba,Fumihito Muro,Hideko Hoh,Atsushi Nakayama
申请号:
US13573673
公开号:
US20130065882A1
申请日:
2012.10.03
申请国别(地区):
US
年份:
2013
代理人:
摘要:
This invention relates to a VLA-4 inhibitory drug, having good oral absorbability and exhibiting sufficient anti-inflammatory effects when administered orally, wherein an active ingredient is represented by formula (I), or a salt thereof:Q represents an optionally-substituted monocyclic or bicyclic nitrogen-containing heterocyclic group having a nitrogen atom as the bonding site; Y represents an oxygen atom or CH2; W represents an optionally-substituted bicyclic aromatic hydrocarbon ring group or an optionally-substituted bicyclic aromatic heterocyclic group; A1 represents a nitrogen atom or C—R3d wherein R3d represents a hydrogen atom, a halogen atom, a C1-8 alkoxy group or a C1-8 alkyl group; R1 represents H or a C1-8 alkyl group; R2 represents H, a halogen, a C1-8 alkoxy
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