PROBLEM TO BE SOLVED: Highly safe Tie2 activator, angiogenesis inhibitor, and blood vessel having excellent Tie2 activating action, angiogenesis inhibiting action, blood vessel maturating action, blood vessel normalizing action, and blood vessel stabilizing action. Maturating agent, blood vessel normalizing agent, blood vessel stabilizing agent, and food and drink. SOLUTION: A Tie2 activator containing, as an active ingredient, at least one of a water extract of a chrysanthemum flower part, a hydrophilic solvent extract, and a mixed solvent extract of water and a hydrophilic solvent, and vascular maturation. Agents, blood vessel stabilizers, and foods and drinks. [Selection diagram] None【課題】優れたＴｉｅ２活性化作用、血管新生抑制作用、血管の成熟化作用、血管の正常化作用、及び血管の安定化作用を有する安全性の高いＴｉｅ２活性化剤、血管新生抑制剤、血管の成熟化剤、血管の正常化剤、及び血管の安定化剤、並びに飲食品の提供。【解決手段】菊の花部の水抽出物、親水性溶媒抽出物、及び水と親水性溶媒との混合溶媒抽出物の少なくともいずれかを有効成分として含有するＴｉｅ２活性化剤、血管の成熟化剤、及び血管の安定化剤、並びに飲食品である。【選択図】なし
