The present invention relates to the use of a compound of general Formula (1),for the treatment of diseases characterized by abnormal cell proliferation ina human or non-human mammalian body by inhibition of polo like kinases asmitotic regulators like cancer selected from the group consisting ofcarcinomas, sarcomas, melanomas, myeloma, hematologic neoplasias, lymphomas,childhood cancers and leukemia, autoimmune disorders selected from the groupconsisting of amyloidosis, systemic lupus erythematosus, rheumatoid arthritis,Crohn~s disease, multiphe sclerosis, systemic sclerosis (scleroderma), mixedconnective tissue disease, Sjögren~s syndrome, ankylosing spondylitis,autoimmune vasculitis, Behcet~s syndrome, psoriasis, autoimmune arthritis,sarcoidosis, diabetes mellitus and fungous diseases.
