CHEN, YI,CUSHING, TIMOTHY D.,DUQUETTE, JASON A.,GONZALEZ LOPEZ DE TURISO, FELIX,HAO, XIAOLIN,HE, XIAO,LUCAS, BRIAN,MCGEE, LAWRENCE R.,REICHELT, ANDREAS,RZASA, ROBERT M.,SEGANISH, JENNIFER,SHIN, YOUNGS
申请号：
CA2681136
公开号：
CA2681136C
申请日:
2008.03.24
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
Substituted bicyclic heteroaryls of the formula:(see above formula)and compositions containing them, for the treatment of general inflammation,arthritis,rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatoryeyedisorders, inflammatory or unstable bladder disorders, psoriasis, skincomplaints withinflammatory components, chronic inflammatory conditions, including but notrestrictedto autoimmune diseases such as systemic lupus erythematosis (SLE), myesteniagravis,rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathicthrombocytopenicpurpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolyticanemia,allergic conditions including all forms of hypersensitivity. The presentinvention alsoenables methods for treating cancers that are mediated, dependent on, orassociated withp110 activity, including but not restricted to leukemias, such as acutemyeloid leukaemia(AML), myelo-dysplastic syndrome (MDS), myelo-proliferative diseases (MPD),chronicmyeloid leukemia (CML), T-cell acute lymphoblastic leukaemia (T-ALL), B-cellacutelymphoblastic leukaemia (B-ALL), non Hodgkins lymphoma (NHL), B-cell lymphomaand solid tumors, such as breast cancer.
