Substituted bicyclic heteroaryls of formula(see above Formula)and compositions containing them, for the treatment of general inflammation,arthritis,rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatoryeyedisorders, inflammatory or unstable bladder disorders, psoriasis, skincomplaints withinflammatory components, chronic inflammatory conditions, including but notrestrictedto autoimmune diseases such as systemic lupus erythematosis (SLE), myesteniagravis,rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathicthrombocytopenicpurpura, multiple sclerosis, Sjoegren's syndrome and autoimmune hemolyticanemia,allergic conditions including all forms of hypersensitivity, The presentinvention alsoenables methods for treating cancers that are mediated, dependent on orassociated withp 110 activity, including but not restricted to leukemias, such as AcuteMyeloid leukaemia(AML), Myelo-dysplastic syndrome (MDS), myelo-proliferative diseases (MPD),Chronic Myeloid Leukemia (CML), T-cell Acute Lymphoblastic leukaemia ( T-ALL),13-cell Acute Lymphoblastic leukaemia (B-ALL), Non Hodgkins Lymphoma (NHL), B-celllymphoma and solid tumors, such as breast cancer.
