Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegrens syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia ( T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.La présente invention concerne des hétéroaryles bicycliques substitués et des compositions les contenant, destinés au traitement dune inflammation générale, de larthrite, de maladies rhumatismales, de lostéoarthrite, daffections intestinales inflammatoires, de troubles inflammatoires oculaires, de troubles inflammatoires ou dinstabilité vésicales, du psoriasis, daffections cutanées à composante inflammatoire, de maladies inflammatoires chroniques, comprenant entre autres des maladies auto-immunes comme le lupus érythémateux disséminé (SLE), la myasthénie grave, la polyarthrite rhumatoïde, lencéphalomyélite aiguë post-infectieuse, le purpura thrombocytopénique idiopathique, la sclérose en plaques, le syndrome de Sjoegren et lhémolyse auto-immune, des maladies allergiques y compris toutes les formes dhypersensibi
