The present application relates to new uses of 5-HT6 receptor antagonists, specifically 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline or pharmaceutically acceptable salts, hydrates, solvates, or polymorphs, thereof, and to the combination of 5-HT6 receptor antagonists, specifically 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline or pharmaceutically acceptable salts, hydrates, solvates, or polymorphs, thereof, with other therapeutic agents for the treatment of a neurodegenerative disease.本申請案係關於5-HT6受體拮抗劑,特言之3-苯基磺醯基-8-哌基-1基-喹啉或其醫藥上可接受鹽類、水合物、溶劑化物或多形物之新用途,以及5-HT6受體拮抗劑,特言之3-苯基磺醯基-8-哌基-1基-喹啉或其醫藥上可接受鹽類、水合物、溶劑化物或多形物與其他用於治療神經退化性疾病之治療劑的組合。