Provided herein are pharmaceutical compositions, each comprising a phenylsulfonamide, for example, a compound of Formula I, or an enantiomer, a mixture of enantiomers, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotopic variant thereof； or a pharmaceutically acceptable salt, solvate, hydrate, or prodrug thereof； and a pharmaceutically acceptable excipient. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a neurodegenerative disease.本發明提供醫藥組合物，每一醫藥組合物包含苯基磺醯胺(例如，式I化合物，或其對映異構體、對映異構體之混合物、兩種或更多種非對映異構體之混合物、互變異構體、兩種或更多種互變異構體之混合物、或同位素變異體)；或其醫藥上可接受之鹽、溶劑合物、水合物或前藥；及醫藥上可接受之賦形劑。本發明亦提供其等用於治療、預防或改善神經退化性疾病之一或多種症狀的方法。
