Describes the use of a compound of formula I wherein X is o, S, so or SO2； r1 is - Oh, trihalogenometilo, halogen, alkyl of C1 - 7, c1-4 alkoxy, trifluoromethoxy, phenoxy, ciclohexilmetiloxi, piridilmetoxi, cinamiloxi, naftilmetoxi fenoximetilo - CH2 - Oh,,, - CH2 - CH2 - Oh, alkyl (c1-4) - Uncle Alkyl (c1-4) sulfinilo, (c1-4 alkyl sulfonyl), benciltio, acetyl, Nitro or cyano, or phenylPHENYL alkyl or phenyl c1-4 alkoxy of C1 - 4 each group phenyl optionally substituted with the same Halogen, CF3, c1-4 alkoxy or alkyl of C1 - 4； R2 is H, halogen, alkoxy trihalogenometilo, c1-4 alkyl of C1, phenethyl Benzyloxy - 7, or； R3 h, halogen, CF3, Oh, alkyl of C1 - 7 Alkoxy, of c1-4 alkoxy, Benzyloxy phenyl or Methyl (c1-4)； each R4 and R5,Is independently H or a residue of the formula (a) wherein each of R8 and R9 independently is H or alkyl, optionally substituted by Halogen C1 - 4； and N is an integer from 1 to 4； or a pharmaceutically acceptable Salt, solvate, hydrate, or isomer prodrug L； or a compound of the formula II in which trihalogenometilo A1A is Halogen, alkyl of C1 - 4Alkoxy alkyl of C1 - 4 (c1-4 alkyl) - Uncle (C1) - 4 - (sulfinilo, c1-4 alkyl sulfonyl phenoxy), aralquilo, optionally substituted or aralquiloxi； trihalogenometilo 2a is H, alkyl, halogen, c1-4 alkoxy, C1 - 4, aralquilo or aralquiloxi； R3A is H, halogen, CF3, c1-4 alkyl, alkoxy of c1-4, alq UIL (c1-4) - Uncle or Benzyloxy； R4A is H, alkyl, phenyl c1-4,BENZYL or optionally substituted benzoyl or lower aliphatic acyl of C1 - 5； r5a is H, monohalogenometilo, c1-4 alkyl, alkoxy (c1-4 alkyl (C1) - methyl - 4 - tiometilo), hydroxyethyl, hydroxypropyl, phenyl, aralquilo, alquenilo C2 or C2 - 4 4 alquinilo； r6a is H or alkyl of C1 - R7a is H, 4； Or a c1-4 alkyl residue of the formula (a) as defined above, XA is o, S,So or SO2； and N is an integer of 1 to 4； or a pharmaceutically acceptable Salt, solvate, hydrate, isomer or prodrug thereof, in the manufacture of a Medicament for the Treatment or prophylaxi
