Derivatives of 2,3 dihydro - 1H imidazo [1,2-a] pyrimidine 5 - one and - 1,2,3,4 tetrahydro - pirimido {1,2} - pyrimidine - 6 - One containing a substituted morpholine, its preparation and pharmaceutical use
JEAN LETALLEC,BERTRAND PHILIPPE - VIVET,YOUSSEF EL-AHMAD,GILBERT MARCINIAK,BAPTISTE RONAN,BRUNO FILOCHE-ROMME
申请号：
ARP130102165
公开号：
AR091498A1
申请日:
2013.06.19
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
Mainly anti-cancer drugs Claim 1: Formula product (1),P and Q represent integers 0 or 1 or 2, if P = 0, q = 1 or 2, if P = 1 or 2, q = 0； R1 is selected from the following values (a) to (E): (a) R1 represents a phenyl or pyridyl radical substance, which can be optionally replaced by one or more of the same or different radical substances, from the halogen protons and c. Cyclopropyl, tar and alcoxi type radicals, the latter being tar and alcoxi type radicals, can be optionally replaced by one or more fluorine atoms； (b) r 1 represents one radical - (ch832244)； - r7491m represents integer 1 or 2, r74919 represents one cathode or heteroradical, and can be optionally replaced；-Cycloquilo, CO heterosexual, co-r74955,-C (R) 3DN-OR-CO R o -CONR R(c) R1 represents a tar, cycloformyl, isocyclopropyl, or an optional tar, which is replaced by one or more of the same or different matrices selected from the fluorine atom and the hydroxyl group, cycloformyl, isocyclopropyl, phenyl, pyridine, and propyl group, the latter being phenyl, e. Piridina and alcoxi are replaced by one or more fluorine atoms by themselves； (d) R1 represents a radical-so832225-r7495；(e) R1 stands for radical - co-r7497；R749595 is an alternative tar, cyclopropene, arilo or isopropene radical substitute； r758080 is a hydrogen atom or radical tar； r7496 is a radical tar or cyclopropene； r74977 is an alternative tar, cyclopropyl compound, isopropene, arilo or isopropene radical substitute； r739； r696 is the case； R739 and r696 are the same or different. They can choose between hydrogen atom and tar, cyclomethyl, propoxy and phenyl, or r739 and r6966 can form a periodic radical composed of 3 to 7 links with nitrogen atom, and can choose one or more selected heteroatoms between O, s, NH and n-tar；R2 and R3,2. The same or different is to choose between a hydrogen atom and an optional radical tar replaced by one or more fluorine atoms, on the understanding that R2 and R3 do not represent 2 CF 83323 and R2 and R3 do
