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Heterocyclic derivatives which have activity of PGD2 receptor antagonist
专利权人:
SHIONOGI & CO.; LTD.
发明人:
申请号:
ARP120103985
公开号:
AR089653A1
申请日:
2012.10.24
申请国别(地区):
AR
年份:
2014
代理人:
摘要:
Composiciones farmac uticas que las contienen Reivindicaci n 1 Un compuesto caracterizado porque tiene la f rmula general (1) en donde el anillo A es un heterociclo no arom tico que contiene nitr geno o un heterociclo arom tico que contiene nitr geno el anillo B es un -X 3D es -N 3D o -C (R) 3D-X 3D es -N 3D o -C (R) 3D-X 3D es -N o -C (R) 3D-X⁵ = is -N = or -C (R¹²) =;Where the number of n is on the ring of - X1 =,-X2X3 = y x830808 = 0, 1 or 2; R1,R2,R3 and r83088 are independent hydrogen atoms, halogen, cyanogen, substituted or unsubstituted tar, substituted or unsubstituted tar, aromatic carbohydrate, substituted or unsubstituted non aromatic carbohydrate, substituted or unsubstituted aromatic heterocycle, substituted or unsubstituted aromatic heterocycle; Or non aromatic bicycles are replaced or not replaced; or two groups are selected from R1,R2,R3 and r830808 combine with surrounding ring carbon atoms to form tar which can be replaced or not replaced by one or two heteroatoms; R1 square is hydrogen atom, or substituted or not replaced tar; r8309es formula: - l-r8313;wherein R⁹ is carboxy, alkyloxycarbonyl or a carboxy equivalent; -L- is substituted or unsubstituted alkylene, substituted or unsubstituted alkenylene, or substituted or unsubstituted alkynylene; R⁶ is independently halogen, hydroxy, carboxy, formyl, formyloxy, sulfanyl, sulfino, sulfo, thioformyl, thiocarboxy, dithiocarboxy, cyano, nitro, nitroso, azido, amidino, guanidine, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, alkynyl substituted or unsubstituted, substituted or unsubstituted alkyloxy, substituted or unsubstituted alkenyloxy, substituted or unsubstituted alkynyloxy, substituted or unsubstituted alkylcarbonyl,Substituted or unsubstituted calcium, substituted or unsubstituted carbide tar, substituted or unsubstituted amino group, substituted or unsubstituted alkylsulfonylfluoride, substituted or unsubstituted alkylsulfonylfluoride, substituted or unsubstituted py
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