A wireless bio-signal detection and classification system for receiving, processing, wirelessly communicating and displaying bio-signal information is provided, inclusive of an analog front-end acquisition circuit with chopper stabilization and sigma-delta modulation technique, a digital signal processor(DSP) with disease classification, a digital controller with functions of encoding/decoding (CODEC), modulation/demodulation (MODEM) and data loss prevention in communication, and a wireless radio frequency (RF) transceiver with super-regenerative technique. The system can detect the real time bio-signal and transmit the data to the server by wireless communication. If the wireless communication is disconnected, the system would immediately store the data until the communication is reconnected. Therefore, the stored data will not be lost and can be transmitted with the real-time data as the communication is re-established. Moreover, the invention provides a bio-signal analysis device and a bio-signal detection device.