經雙取代之苯并噻吩基-吡咯并三及其用途农业专利-农业学术服务平台

发明人:: BROHM, DIRK,布罗姆　德克,布羅姆　德克,HEROULT, MELANIE,赫鲁特　梅勒妮,赫魯特　梅勒妮,COLLIN, MARIE-PIERRE,柯林　玛莉皮尔,柯林　瑪莉皮爾,HUEBSCH, WALTER,赫布胥　瓦勒特,LOBELL, MARIO,罗贝尔　马力欧,羅貝爾　馬力歐,LUSTIG, KLEMENS,勒斯蒂格　克莱门斯,勒斯蒂格　克萊門斯,GRUENE,布罗姆德克,布羅姆德克,赫鲁特梅勒妮,赫魯特梅勒妮,柯林玛莉皮尔,柯林瑪莉皮爾,赫布胥瓦勒特,罗贝尔马力欧,羅貝爾馬力歐,勒斯蒂格克莱门斯,勒斯蒂格克萊門斯

摘要：: This invention relates to novel substituted 5-(1-benzothiophen-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives having protein tyrosine kinase inhibitory activities, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating proliferative disorders, in particular cancer and tumor diseases.本發明係有關具有蛋白質酪胺酸激酶抑制劑活性之新穎之經取代之5-(1-苯并噻吩-2-基)吡咯并[2,1-f][1,2,4]三-4-胺衍生物、此等化合物之製法、包含此等化合物之醫藥組合物、及此等化合物或組合物於治療增生性病變，特定言之癌症與腫瘤疾病上之用途。