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A NEW FORM FOR INTRODUCING OSTEOGENIC PROTEIN COMPLEXES
专利权人:
АДОСИА
发明人:
СУЛА Жерар,СУЛА Реми,СУЛА Оливье
申请号:
RU2011124917
公开号:
RU2011124917A
申请日:
2009.11.19
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. A co-precipitate consisting of at least one osteogenic protein complex with an anionic polysaccharide in its insoluble form and at least one insoluble calcium salt, wherein said co-precipitate is in ground form. The co-precipitate according to claim 1, wherein the insoluble calcium salt is selected from the group consisting of calcium orthophosphates in anhydrous or hydrated form, used individually or in a mixture. The co-precipitate according to claim 1, wherein the insoluble calcium salt is selected from the group consisting of mixed salts formed by cationic calcium ions and anionic ions, such as mono-, di- or tribasic phosphates, polysaccharide carboxylates, carbonates, hydroxides and possible anions, which contained in the grounds. 4. A co-precipitate according to any one of claims 1 to 3, which further comprises at least one growth factor having chemoattractive and angiogenic activity. A co-precipitate according to one of claims 1 to 3, characterized in that the anionic polysaccharide is selected from the group consisting of polysaccharides containing carboxyl functional groups partially substituted by hydrophobic alcohols of the general formula IX: where q is the molar fraction of the carboxyl functional groups of the polysaccharide substituted by FRG -Ah, and ranges from 0.01 to 0.7, - F 'means an amide functional group, - G means an ester, thio-ester, carbonate or carbamate functional group, - R means a chain containing 1-18 carbon atoms an ode optionally branched and / or unsaturated, optionally containing one or more heteroatoms, such as O, N and / or S, and having at least one acidic1. Сопреципитат, состоящий по меньшей мере из одного комплекса остеогенного белка с анионным полисахаридом в его нерастворенной форме и по меньшей мере одной нерастворимой соли кальция, при этом указанный сопреципитат находится в измельченной форме.2. Сопреципитат по п.1, в котором нерастворимая соль кальция выбрана из группы, состоящей из ортофосфатов кальция в безводной и
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