КРИКМОР Джозеф Ричард (US),КОТАРИ Санджив Хукмичанд (US),МУИЛЛЕР Брэдфорд Дж. (US),ПЭН Йинсюн (US)
申请号：
RU2013154037/15
公开号：
RU2013154037A
申请日:
2012.05.17
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A method of manufacturing a pharmaceutical dosage form comprising a layer containing the calcium salt of rosuvastatin, comprising applying the coating by spraying a solution containing the calcium salt of rosuvastatin and the first coating forming polymer in water to the tablet core, pills or granuly.2. . A method according to claim 1, comprising: a) coating the core tablets, pills or granules sublayer second forming coating ib resin) coating solution spray coating containing the calcium salt of rosuvastatin and the first forming coating polymer in water, on the coated core tablet, pills or granules obtaining the layer containing the calcium salt rozuvastatina.3. . The process according to 1 or 2, comprising: a) optionally coating the tablet core, pills or granules sublayer second forming polymer coating b) applying a coating comprising a calcium salt solution spray rosuvastatin and first polymer in water forming a coating on the (possibly coated) core tablet, pills or granules to obtain the layer containing the calcium salt of rosuvastatin and c) a coating layer containing the calcium salt of rosuvastatin, outer coating comprising forming the third coating polimer.4. A method according to Claim. 1, where the core tablet, pills or granules containing the active ingredient which is not a calcium salt rozuvastatina.5. A method according to claim 4, wherein the core contains an active ingredient which is selected from any one or more of the following:. Niacin analog or niacin, a fibrate, metformin, the CETP inhibitor (transfer protein cholesteryl ester) and / or aspirin.6. A method according to claim. 4 or 5, wherein the core contains an active ingredient selected from sulfonilmoche1. Способ изготовления фармацевтической лекарственной формы, содержащей слой, содержащий кальциевую соль розувастатина, включающий нанесение покрытия распылением раствора, содержащего кальциевую соль розувастатина и первый формирующий покрытие полимер в воде, на ядро таблетки, пилюли или
