1. A method of coating the substrate surface with a pharmaceutical composition which comprises a biologically active thrombin, the substrate comprises collagen or gelatin, wherein said method includes the use of ultrasound technology raspyleniya.2. A method according to claim 1, wherein the pharmaceutical composition further comprises one or more biologically active agents are selected from the group consisting of endothelium Tissue Factor (TF), Factor VII, TF-Factor VIIa, Factor IX, Factor X, activated factor II ( factor IIa), factor XIa, plasmin, factor XII, factor Xa, TFPI, factor Va, prothrombinase complex, prothrombin, factor V, factor XI, factor VIII, vWF, factor VIIIa, factor IXa and tenaznogo kompleksa.3. A method according to claim 1, wherein the pharmaceutical composition further comprises fibrinogen.4. The method of claim 1, wherein said pharmaceutical composition contains calcium, albumin, mannitol and atsetat.5. A method according to claim 1 wherein the base to be spray coating: a. loaded onto a transport mechanism, b. is conveyed to a spray chamber, with. performing spray coating, d. transported to a drying area, e. dried, f. is subjected to momentary cooling, g. transported to an area for packaging and zaversheniih. upakovyvayut.6. The method of claim 1, wherein the ultrasonic atomization technology used vklyuchaeta. system for providing a pharmaceutical composition (s) which is to be spray coating on a substrate, and b. one or more configurations of spray nozzles, comprising one or more spray nozzles for the atomization of a pharmaceutical composition and direction of the atomized F1. Способ покрытия поверхности основы фармацевтической композицией, которая содержит биологически активный тромбин, при этом основа содержит коллаген или желатин, где указанный способ включает использование технологии ультразвукового распыления.2. Способ по п.1, где фармацевтическая композиция дополнительно содержит одно или несколько биологически активных средств, которые
