< Topic >As it is encapsulated by the lipophilic biodegradation Characteristic polymer, or the copolymer it includes the human IXth factor which formed the microsphere, extends the discharge of human IXth factor, after the frozen dehydration way there is no remaining behind of the organicity solution, new powder, the formulation of configuration and offer of its production manner.SolutionsThis invention is encapsulated by the lipophilic biodegradation Characteristic polymer or the copolymer, as included the therapeutically effective amount of the human IXth factor (hFIX) which, formed the microsphere powder offers the formulation of configuration, the said formulation the controlled release conversion of hFIX offers the biological activity which is extended.< Choice figure >Drawing 1【課題】親油性生分解性ポリマーまたはコポリマーによってカプセル化され、マイクロスフェアを形成したヒト第IX因子を含み、ヒト第IX因子の放出を延長すると共に、凍結乾燥後に有機溶液の残留がない、新しい粉末様形態の製剤及びその製造方法の提供。【解決手段】本発明は、親油性生分解性ポリマーまたはコポリマーによりカプセル化され、マイクロスフェアを形成したヒト第IX因子(hFIX)の治療有効量を含む粉末様形態の製剤を提供し、該製剤がhFIXの徐放化と延長された生物活性を提供する。【選択図】図1
