The present invention relates to opioid and opioid-like compounds, and pharmaceutical formulations containing the same and methods of use thereof. Uses of the present invention include, but are not limited to, use for the prevention and treatment of septic shock, organ damage, and other disorders. The compounds described herein can be water soluble and can act through mechanisms mediated through pathways other than opiate receptors.本發明係關於類鴉片與類似之類鴉片化合物,及含有彼等之醫藥配方,以及其使用方法。本發明之用途包括但不限於預防與治療敗血性休克、器官傷害及其他病症之用途。本文中所述之化合物可為水溶性,並可經過鴉片製劑受體以外之途徑所媒介之機制發生作用。