MIURA Michiko (US),МИУРА Мичико (US),RENNER Mark V. (US),РЕННЕР Марк В. (US),MIURA MICHIKO,МИУРА Мичико,RENNER MARK V.,РЕННЕР Марк В.
申请号：
RU2009121323/04
公开号：
RU0002477161C2
申请日:
2007.12.03
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
FIELD: medicine.SUBSTANCE: present invention refers to a boron-containing compound of formula: wherein R1, R2, R3 and R4 independently mean -NO2, halogen or a substitute presented by the following formula wherein the substitutes Y are independently found in an ortho-, meta- or para- position on a phenyl ring, and independently mean hydrogen or a substitute presented by formula : provided at least one of R1, R2, R3 and R4 means a substitute presented by formula (2) wherein Y is presented by formula (3)； wherein: X means oxygen or sulphur； R10 and R11 are independently specified in hydrogen and C1-C4 hydrocarbonyl； Z means a carborane cluster containing at least two carbon atoms and at least three boron atoms, or at least one carbon atom or at least five boron atoms in a frame structure； r means 0 or an integer within 1 to 20； a means an integer within 1 to 4； and also provided at least one of R1, R2, R3 and R4 means a substitute presented by -NO2 or halogen； and M means either two hydrogen ions, or a two-valence metal ion, a three-valence metal ion, a four-valence metal ion with a charge of the porphirine-metal complex formed by the three-valence or four-valence metal ion being neutralised by a corresponding number of counteranions, dianions. There are also presented a method for visualising a tumour and surrounding tissues, and a method for bimodal therapy of cancer.EFFECT: invention provides preparing carboranylporphyrines with a prolonged tumour time selectively targeted on tumour cells and destructing them with minimal involvement of healthy tissues.24 cl, 4 tbl, 12 exНастоящее изобретение относится к борсодержащему соединению формулы:где R1, R2, R3 и R4, независимо, обозначают -NO2, галоген или заместитель, представленный следующей формулой ；где заместители Y, независимо, находятся в орто-, мета- или параположении в фенильном кольце и, независимо, обозначают водород или заместитель, представленный формулой (3):；при условии, что, по меньшей мере, один из R1, R
